Antihistamines may help resolve long COVID, report suggests

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Two healthy middle-aged woman After taking daily antihistamines for a long time, I returned to my normal daily life. COVIDAccording to a recently published case Report..

The researcher Long COVID is a chronic sign that patients infected with the virus show symptoms that persist beyond the normal time frame for the infection to resolve, but now the disease has evidence to guide how to manage it. There is no cure based on. ..

“Most patients say they don’t recommend anything that helped their health care providers,” said Melissa Pinto, an associate professor at the University of California, Irvine and Birgros Nursing School. Stated.

The report describes the first case of a Caucasian female in her 40s with a past medical history. Raynaud’s phenomenon (A state in which blood flow to the finger is reduced), Polycystic ovary syndrome (Hormonal disorders of the ovaries), and milk allergies.

According to her, she is likely to be one of the first known people to be infected with COVID-19 in the United States. Science Alert..

A sick young woman lying on the couch and holding her head in her hands.

A sick young woman lying on the couch and holding her head in her hands.
(IStock)

Within 72 hours of diagnosis, a female health care worker complained of “severe malaise, malaise, and headache,” after which the rash progressed and spread one week after the first symptoms.

According to the paper, she partially resolved her symptoms 24 hours later, but two months after her diagnosis, she began to feel fog in the brain with the recurrence of symptoms, prompting a comprehensive work-up that did not reveal it. rice field.

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She took 50 mg of an antihistamine after accidentally ingesting cheese known to be allergic about 6 months after her illness. DiphenhydramineHowever, I happened to notice a significant reduction in her ongoing fatigue.

According to case reports, she resumed diphenhydramine three days after her symptoms recurred and continued to take it daily for six months until her doctor switched to hydroxyzine 25 mg, which she was instructed to titrate until her symptoms disappeared. ..

She eventually increased it by 50 mg, returned 90% to baseline functional status, and now maintained it for 9 months without recurrence.

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The report described a similar case of a middle-aged Caucasian female teacher who had an unobtrusive past medical history except: asthma Seasonal allergies she treated with the antihistamine fexofenadine.

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She reportedly may have been infected with COVID-19 from her child who had symptoms compatible with the virus, but her symptoms persisted for 9 months, resulting in fatigue and concentration. It was accompanied by a decline.

However, when she ran out of fexofenadine 13 months after her chronic illness, the author accidentally decided to take 25 mg of diphenhydramine instead, and the next day she suffered from brain fog and malaise. He said it was completely resolved.

A young woman sleeping with her laptop closed at work.  She is tired due to long-COVID.

A young woman sleeping with her laptop closed at work. She is tired due to long-COVID.
(IStock)

As a result, she continued to take diphenhydramine daily, and according to case reports, she continued to notice clinical improvements in brain fog, malaise, abdominal pain, and odor loss.

She has been taking 25 mg of diphenhydramine at night and 180 mg of fexofenadine in the morning for more than 60 days, with 95% returning to baseline function, the report said.

One limitation of the report is that more research is needed to generalize to a larger population, given that it is only a case study of two patients. Science Alert..

“Patients say they want to work and do the most basic activities above all before they get sick with a long COVID. They are desperately looking for something to help them recover.” And focus Said..

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“Possibility of over-the-counter sales with easy access dosage Can alleviate some [long COVID] Symptoms should give hope to an estimated 54 million people around the world who are suffering for months or even years. “

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